Flaxseeds
Serving: 2.00 TBS (14g, 75 cal)
Key Nutrients
| Nutrient | Amount | DV% | Rating |
|---|---|---|---|
| omega-3 fats | 3.19 g | 133% | Excellent |
| vitamin B1 | 0.23 mg | 19% | Very Good |
| copper | 0.17 mg | 19% | Very Good |
| manganese | 0.35 mg | 15% | Very Good |
| fiber | 3.82 g | 14% | Good |
| magnesium | 54.88 mg | 13% | Good |
| phosphorus | 89.88 mg | 13% | Good |
| selenium | 3.56 mcg | 6% | Good |
| tryptophan | 0.04 g | 12.5% | Good |
| omega 3 fatty acids | 4.79 g | 199.6% | Excellent |
omega-3 fats
Excellentvitamin B1
Very Goodcopper
Very Goodmanganese
Very Goodfiber
Goodmagnesium
Goodphosphorus
Goodselenium
Goodtryptophan
Goodomega 3 fatty acids
ExcellentAbout Flaxseeds
What’s new and beneficial about flaxseeds
- Finding creative ways to add flaxseeds to your meals can be a challenge. One popular technique is to incorporate ground flaxseeds into your muffin, cookie, or bread recipes. Recent research studies have shown that ground flax can be added to baked foods without sacrificing large amounts of alpha-linolenic acid (ALA), their showcase omega-3 fatty acid that accounts for over half of their total fat content. Oven temperatures of 300F (150C) - even over several hours of baking time - do not appear to substantially reduce the amount of ALA in baked products. This outcome has been demonstrated for breads, muffins and cookies. Even when flaxseeds are ground prior to incorporation into breads and pastas, these preparation methods - involving grinding prior to heating - only appear to lower ALA levels by about 4-8%. Interestingly, bread enriched with ground flaxseed has also been shown to have a greater antioxidant capacity and a much lower glycemic index value (of approximately 51) than the same bread without the ground flaxseed addition. These research findings are great news for anyone who wants to include flaxseeds in baked dishes, in either whole or ground form.
- Most plant foods contain at least small amounts of phytonutrients called lignans. Lignans are unique fiber-related polyphenols that provide us with antioxidant benefits, fiber-like benefits, and also act as phytoestrogens. Among all commonly eaten foods, researchers now rank flaxseeds as the #1 source of lignans in human diets. Flaxseeds contain about 7 times as many lignans as the closest runner-up food (sesame seeds). They contain about 338 times as many lignans as sunflower seeds, 475 times as many as cashew nuts, and 3,200 times as many lignans as peanuts.
- Vegetables and fruits are the most familiar sources of antioxidants. According to recent research, flaxseeds also rank high among antioxidant-dense foods. When flaxseeds are compared with other commonly eaten foods in terms of their total polyphenol content (polyphenols are one very important group of antioxidants), flaxseeds rank 9th among 100 commonly eaten foods. Flaxseeds turn out to be significantly higher in polyphenol antioxidants than fruits like blueberries or vegetables like olives. The antioxidant benefits of flaxseeds have long been associated with prevention of cardiovascular diseases and have recently also been tied to decreased insulin resistance.
- Given the strong track record of flaxseeds as foods providing cardiovascular support, it’s not surprising to see recent research studies showing potential benefits of flaxseeds for intervention in metabolic syndrome (MetS). One recent study showed a 20% decrease in the prevalence of MetS (in persons already diagnosed with MetS) after 12 weeks on a diet plan that included 30 grams (1 ounce) of ground flaxseed per day in the form of flaxseed-enriched baked bread. Interestingly, in addition to improving blood pressure and lowering fasting glucose level in study participants, flaxseed intake also helped decrease their central obesity (as measured by waist circumference). The addition of flaxseed provided all of these benefits without causing weight gain. That’s quite an accomplishment for a food that is over 70% fat in terms of total calories and contains about 10 times as many calories per cup as a fruit like blueberries.
Flaxseeds, ground, raw
2.00 TBS
(14.00 grams)
Calories: 75
GI: very low
NutrientDRI/DV
omega-3 fats133%
copper19%
vitamin B119%
manganese15%
fiber14%
phosphorus13%
magnesium13%
selenium6%
- Health Benefits
- Description
- History
- How to Select and Store
- Tips for Preparing and Cooking
- How to Enjoy
- Nutritional Profile
- References
Health benefits
Flaxseeds are nutritionally distinct from other seeds in three specific ways, each contributing to their documented health benefits.
Three distinguishing nutrient features
The first is omega-3 fatty acid content. Flaxseeds are among the richest plant sources of omega-3s. The primary omega-3 fatty acid found in flaxseeds is alpha-linolenic acid, or ALA. The ALA in flaxseed has found to be stable for at least 3 hours of cooking at oven temperatures (approximately 300F/150C), which makes it available after ground flaxseeds have been added to baked goods like muffins or breads.
The second unique feature of flaxseed is its lignans. Lignans are fiber-like compounds, but in addition to their fiber-like benefits, they also provide antioxidant protection due to their structure as polyphenols. The unique structure of lignans gives them a further health-supportive role to play, however, in the form of phytoestrogens. Along with isoflavones, lignans are one of the few naturally occurring compounds in food that function as weak or moderate estrogens when consumed by humans. Among all foods commonly eaten by humans, researchers rank flaxseeds as the number one source of lignans. Sesame seeds come in second, but contain only one-seventh of the total lignans as flaxseeds. To give a few further examples, sunflower seeds contain about 1/350th as many lignans, and cashews nuts contain about 1/475th as many lignans as flaxseeds.
A third unique feature of flaxseeds is their mucilage (gum) content. “Mucilage” refers to water-soluble, gel-forming fiber that can provide special support to the intestinal tract. For example, gums can help prevent the rapid emptying of the stomach contents into the small intestine, thereby improving absorption of certain nutrients in the small intestine. Arabinoxylans and galactoxylans are included within the mucilage gums found in flaxseeds.
This combination of omega-3 fatty acids, high lignan content and mucilage gums is not found in other commonly eaten nuts or seeds. The health benefits described below draw from this distinctive nutrient profile.
Cardiovascular benefits
The primary omega-3 fatty acid in flaxseeds—alpha-linolenic acid, or ALA—can be helpful to the cardiovascular system in and of itself. As the building block for other messaging molecules that help prevent excessive inflammation, ALA can help protect the blood vessels from inflammatory damage. Numerous studies have shown the ability of dietary flaxseeds to increase our blood levels of ALA, even when those flaxseeds have been ground and incorporated into baked goods like breads or muffins. When flaxseeds are consumed, two other omega-3 fatty acids have also been shown to increase in the bloodstream, namely, eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA). Increases in EPA and DPA also help provide inflammatory protection.
Protection of our blood vessels from inflammatory damage can also be provided by the lignans in flaxseeds. These lignans can inhibit formation of platelet activating factor (PAF), which increases risk of inflammation when produced in excessive amounts. The overall anti-inflammatory benefits of ALA and lignans in flaxseeds has been further corroborated by studies in which flaxseed-enriched baked goods (like muffins) lead to decreases of 10-15% in C-reactive protein (CRP) levels. CRP levels are a commonly used indicator of inflammatory status in the whole body.
Risk of oxidative stress in the blood vessels can also be lowered by flaxseed intake. In addition to being a very good source of the mineral antioxidant manganese, polyphenols in flaxseed—including flaxseed lignans—provide measurable antioxidant benefits. The antioxidant benefits of one particular flaxseed lignan, secoisolariciresinol, have been especially well-documented. Decreased lipid peroxidation and decreased presence of reactive oxygen species (ROS) in the bloodstream have both been associated with flaxseed intake in amounts of approximately 2 tablespoons per day.
Intake of flaxseeds has also been shown to decrease the ratio of LDL-to-HDL cholesterol in several human studies and to increase the level of apolipoprotein A1, which is the major protein found in HDL cholesterol (the “good” cholesterol). This HDL-related benefit may be partly due to the simple fiber content of flaxseeds, since 2 tablespoons of ground flaxseed provide about 4 grams of dietary fiber.
Although direct studies on flaxseed and blood pressure are limited (and mostly confined to flaxseed oil versus ground flaxseed), numerous studies have shown the ability of increased omega-3 fatty acid intake to help regulate blood pressure and to help reduce blood pressure in persons who have been diagnosed with hypertension. With its excellent content of the omega-3 fatty acid alpha-linolenic acid (ALA), flaxseed can help us increase our overall omega-3 intake and, by doing so, at least potentially decrease our risk of high blood pressure.
There is one area of concern that we want to note involving flaxseeds and the cardiovascular system. We’ve seen one very small-scale study from Canada involving 30 children and teens (ages 8-18), all previously diagnosed with hypercholesterolemia (high cholesterol) and given added flaxseed in their diets over a period of 4 weeks. The flaxseed amount was 2 tablespoons, and the form was ground flaxseeds incorporated into breads and muffins. In this study, blood levels of total cholesterol and LDL cholesterol did not significantly change, but blood fat levels (in the form of triglycerides) increased and HDL cholesterol (the “good” cholesterol) decreased. Since we would consider these changes in blood lipids to be unwanted, we believe this study raises some preliminary questions about the role of daily flaxseeds in amounts of 2 tablespoons or above in the diet of children and teenagers who are already known to have high cholesterol. Much more research is needed in this area, but if you are the parent of a child or teen who is already diagnosed with high cholesterol, we recommend that you consult with your healthcare provider about the pros and cons of incorporating flaxseeds into your child’s meal plan on a daily basis in any substantial amount.
Antioxidant and anti-inflammatory benefits
It is important to realize that the antioxidant and anti-inflammatory benefits of flaxseed do not apply only to the cardiovascular system. Oxidative stress (which is often related to deficient intake of antioxidant nutrients) and excessive inflammation (which can also be related to deficient intake of anti-inflammatory nutrients) are common risk factors for a wide variety of health problems. These problems include development of insulin resistance, type 2 diabetes, asthma, obesity, and metabolic syndrome. There is preliminary evidence that either whole flaxseed intake or its constituents can decrease risk of all the problems above by increasing our anti-inflammatory and antioxidant protection.
Risk reduction for certain types of cancer
The antioxidant and anti-inflammatory benefits of flaxseeds also make them a logical candidate for risk reduction with certain types of cancer. That’s because chronic inflammation (even low-level inflammation) and chronic oxidative stress are theoretical risk factors for cancer development. In the case of flaxseeds, basic science research is strongest for breast cancer, prostate cancer, and colon cancer. We have started to see small clinical trials adding flaxseeds to meal plans for cancer survivors, but to date, they have only focused on short-term outcomes like treatment-related symptoms.
Three of the lignans found in flaxseeds—secoisolariciresinol, matairecinol, and pinoresinol—can be converted by intestinal bacteria into enterolactone (ENL) and enterodiol (END). ENL and END have direct effects on our hormonal balance and in this way may play an especially important role in hormone-related cancer. The relationship between flaxseed intake and cancer risk is complicated, furthermore, by the important and variable role of gut bacteria in converting secoisolariciresinol and other lignans in flax into enterolactone and enterodiol. This conversion process involves many different enzyme-related steps provided by a complicated mix of gut bacteria including Bacteriodes, Bifidobacterium, Butyribacterium, Eubacterium and others.
Support for digestive health
Benefits of flaxseed for the digestive tract—although mentioned earlier throughout this food profile—are worth repeating here. The strong fiber content of flaxseeds—including their mucilaginous fiber—help to delay gastric emptying and can improve intestinal absorption of nutrients. Flaxseed fibers also help to steady the passage of food through our intestines. Finally, the lignans in flaxseed have been of interest to researchers for their potential to reduce cellular changes that could increase risk of colon cancer. This impressive group of digestive tract benefits is likely to receive more attention in future research studies.
Flaxseeds and post-menopausal symptoms
We’ve seen mixed findings regarding the post-menopausal benefits (such as reduction of hot flashes) associated with flaxseed intake, with some studies showing significant benefits and other studies showing a lack of significant benefits. However, there continues to be strong interest in flaxseeds and their components (including enterolactone and secoisolariciresinol diglucoside) as potential aids during management of perimenopausal and postmenopausal symptoms as well as during hormone replacement therapy (HRT).
This area of flaxseed research is admittedly complex. For example, enterolactone made from flaxseed lignans has been shown to be pro-estrogenic (promoting estrogen production, through increased formation of transcription factors like ER-alpha and ER-beta), as well as anti-estrogenic (working against estrogen production, through inhibition of enzymes like estrogen synthetase). It’s also known to lower the activity of 5-alpha-reductase (an enzyme that converts testosterone into dihydrotestosterone) and 17-beta hydroxysteroid dehydrogenase (an enzyme that converts estrone into estradiol). Given this complicated set of circumstances that may vary from one woman to another, it may turn out that flaxseed intake is simply of inconsistent benefit based on individual variation.
Other potential health benefits
Although we’ve already mentioned decreased risk of insulin resistance in relationship to flaxseed intake, we think it is likely we will see more research studies in this area. The strong fiber content, antioxidant content, and anti-inflammatory content of flaxseeds make them a natural here.
One final note about the health benefits of flaxseeds involves their feeding to animals. We’ve seen repeated studies on the content of beef, chicken, and eggs that reflect significantly increased omega-3 content in these foods when flaxseed meal and/or flaxseed oil are added to the diets of cows and chickens. For persons who enjoy these foods in their meal plan on a regular basis, this increased omega-3 content can really add up. Some manufacturers of beef, chicken, and eggs provide omega-3 information on their product packaging. Consumption of certified organic animal foods in which flaxseed was added to the animals’ feed can be an effective way of increasing your omega-3 intake.
Recent research
A 2023 review in Critical Reviews in Food Science and Nutrition (Parikh et al.) addresses a question the existing literature on flaxseed largely sidesteps: the anti-nutritional compounds native to the seed itself. Cyanogenic glycosides, primarily linamarin and lotaustralin, are present in flaxseed and release hydrogen cyanide during metabolic processing. At typical dietary intake levels of roughly two tablespoons per day, the resulting cyanide exposure falls well below established toxic thresholds. Heating, soaking, and fermentation all measurably reduce cyanogenic glycoside content, making food-preparation method a relevant variable when assessing actual exposure.
Phytic acid represents a second category of concern reviewed by Parikh and colleagues. Phytate binds divalent minerals, including iron, zinc, and calcium, and can reduce their intestinal absorption. The review situates this concern carefully: the mineral-binding effect matters most in diets already marginal in these minerals, a condition most common in populations relying heavily on a single staple grain or legume. For individuals consuming varied diets with multiple mineral sources, the phytate content of a two-tablespoon flaxseed serving is unlikely to produce clinically meaningful mineral deficits.
The anticancer findings in the 2023 review consolidate lignan-based evidence but add mechanistic specificity absent from earlier work. Secoisolariciresinol diglucoside (SDG) modulates estrogen metabolism at several points, and the gut-bacterial conversion of SDG to enterolactone and enterodiol now appears to be the rate-limiting step in any downstream protective effects. This conversion depends on a consortia of anaerobic bacteria that varies substantially between individuals. Inter-individual variation in microbiome composition may account for the inconsistent results seen across flaxseed and cancer-risk studies, a finding that complicates any population-level claim about flaxseed’s anticancer properties.
Description
The scientific name for flax—Linum usitatissimum— reveals a lot about our human relationship to this plant. The “linum” part of this name sounds a lot like “linen,” which is a fabric that has been made from flax for over 3,000 years. The “usitatissimum” part of its name means “of greatest use” in Latin, and that quality also rings true in our relationship to flax. This plant has served not only as a food source and source of linen, but also for the creation of sails on sailing ships, bowstrings, and body armor. Flaxseed is known in many parts of the world as “linseed,” although most of the linseed oil sold in the United States is not food grade and is sold instead for use as a wood finish and preservative.
Brown flax and golden flax (sometimes called yellow flax) are the two basic varieties of flax, and they are similar in their nutritional composition. Both can be excellent sources of omega-3 fatty acids (in the form of alpha-linolenic acid) and very good sources of fiber. As with all foods, however, growing conditions and other factors play a key role in determining the quality of harvested flaxseeds, including their nutrient composition. You can find detailed and practical information for selecting high-quality flaxseeds in the “how to select” section in this chapter.
One additional clarification about varieties of flax is also important. New Zealand flax, even though it bears the same name, is not related to the flax plant Linum usitatissimum whose flaxseeds we recommend as a World’s Healthiest Food. New Zealand flax also has a rich history of use for its fiber content, however, as well as traditional medicinal uses as developed by the Maori peoples of New Zealand.
In their raw form, flaxseeds usually range from amber/yellow/gold in color to tan/brown/reddish brown. White or green flaxseeds have typically been harvested before full maturity, and black flaxseeds have typically been harvested long after full maturity.
History
Sometime between 4000 and 2000 BC, flax cultivation became a common practice in countries bordering the Mediterranean Sea and in regions of the Middle East, and there is some evidence that flax cultivation may have started even thousands of years earlier, during the Neolithic Era of approximately 10,000 BC. From the very beginning, the value of flax was both culinary and domestic, since flax fibers could be spun into linen to provide clothing and other textile-related products.
To this day, flax cultivation has remained both culinary and domestic, although crop production has become more specialized and wide scale. In the United States and Canada, most commercial flax production involves oilseed varieties of flax, in which the seeds will eventually be dried and crushed and used to produce different grades of oil. Non-food grade flaxseed/linseed oil is used in wood finishes, paints, coatings, and other industrial supplies. Food grade flaxseed/linseed oil can as be used in livestock feed, or as a culinary oil. (It is much more common, however, for livestock feed to contain flaxseed meal versus flaxseed oil.) Oilseed varieties of flax are typically classified as oilseed crops along with soybeans, rapeseed, cottonseed, sunflower seed, and peanuts. Canada is the world’s largest producer of oilseed flax, followed by Russia, France, and Argentina.
Fiber flax is the other major variety of flax in terms of commercial production. In Europe, France and Belgium are especially large producers of fiber flax. While cotton, wool and silk remain the most popular natural fibers in the global textile market, the global flax market has grown in recent years following increased production of linen products in China.
Alongside of these other flax markets, however, has developed a gradually expanding consumer market for flaxseeds themselves, to be considered as uniquely nourishing food. We expect to see food interest in flaxseeds increase, primarily because of their unique nutrient combinations and health benefits.
How to select and store
How to select flaxseeds
Flaxseeds can be purchased either whole or already ground. The two different forms offer distinct benefits. Because flaxseeds can be very difficult to chew, grinding of the seeds prior to consumption can usually increase their digestibility. However, grinding takes time, and pre-ground flaxseeds can have great convenience. On the other side of the coin, pre-ground flaxseeds—while more convenient—also come with a shorter shelf life than whole flaxseeds.
Whole flaxseeds are generally available in prepackaged containers as well as bulk bins. Just as with any other food that you may purchase in the bulk section, make sure that the bins containing the flaxseeds are covered and that the store has a good product turnover so as to ensure their maximal freshness. Whether purchasing flaxseeds in bulk or in a packaged container, make sure that there is no evidence of moisture.
Certified organic flaxseeds reduce exposure to pesticide residues and heavy metals.
If you purchase whole flaxseeds, either store them in an airtight container in a dark, dry and cool place or place their airtight container directly in the refrigerator.
Ground flaxseeds are usually available both refrigerated and non-refrigerated. If you are purchasing ground flaxseed that is sitting on the store shelf at room temperature, we recommend that the flaxseed be packaged in a gas-flushed, vacuum-sealed bag. If you are purchasing ground flaxseed that is found in the refrigerator section, it’s not essential that vacuum-sealed packaging be used, but it can still be helpful from a food quality standpoint.
How to store flaxseeds
The best way for you to store flaxseeds depends on the form in which you have purchased them. For this reason, we’ve divided up our “how to store” section into the three categories below:
Storage of ground flaxseeds:
Regardless of the form in which you purchase your ground flaxseeds (in vacuum-sealed packaging on the store shelf at room temperature or from a refrigerated case), you should keep them in your home refrigerator after opening. The reason for this precaution is simple: once flaxseeds are ground, they are much more prone to oxidation and spoilage. Similarly, if you are grinding whole flaxseeds on your own at home (for example, in a small spice or coffee grinder), you will want to store them in the refrigerator in an airtight container. If using glass, you may also want to use a darkened glass as that will lessen exposure of the ground flaxseeds to light.
Just to reiterate: even when carefully packaged in a gas-flushed, light-protective pouch, ground flaxseeds should be refrigerated after opening. They will typically store safely for about 6-16 weeks.
Storage of whole flaxseeds:
Whole flaxseeds can typically be stored for 6-12 months if placed in an airtight container in a dark, cool dry spot. They can also be refrigerated, and may safely store for a year or longer using this approach.
Storage of flaxseed oil:
Flaxseed oil is especially perishable and should always be purchased in opaque bottles that have been kept refrigerated.
Tips for preparing and cooking
We recommend the grinding of flaxseeds in a coffee, seed, or spice grinder for easier digestibility. If you are adding ground flaxseeds to a cooked cereal or grain dish, we recommend that you do so at the end of cooking both to reduce the amount of heat exposure to the flaxseeds and help prevent too much thickening of the liquids.
Uncooked flaxseeds can make a great addition to cereals, snacks, and dressings. One great example of this approach is the Quinoa Breakfast Bowl in our WHF Meal Plan! Another great example is our Dijon Flaxseed Dressing.
Because the omega-3 fatty acids in flaxseeds are surprisingly heat stable, we also recommend their use in baking. Muffins and breads are examples of baked items that can be given a major nutritional boost through addition of flaxseeds.
We do not recommend the use of flaxseed oil in cooking, since we believe it is too easily damaged by cooking heats. However, we believe it is fine to add flaxseed oil to foods after they have been cooked. For more on our recommendations on flaxseed oil, please see our website article dedicated to this topic.
How to enjoy
Serving ideas
- Sprinkle ground flaxseeds onto your hot or cold cereal.
- Add flaxseeds to your homemade muffin, cookie or bread recipe.
- To pump up the nutritional volume of your breakfast shake, add ground flaxseeds.
- To give cooked vegetables a nuttier flavor, sprinkle some ground flaxseeds on top of them.
- Add a tablespoon of flaxseed oil to smoothies.
Nutritional profile
Among commonly eaten foods, flaxseeds are an unparalleled source of fiber-related polyphenols called lignans. They are also an unusual source of mucilaginous gums like arabinoxylans and galactoxylans.
Two TBS (14g) at 75 calories provides omega 3 fatty acids (199.6% DV), omega-3 fats (133% DV), vitamin B1 (19% DV), copper (19% DV), manganese (15% DV), fiber (14% DV), magnesium (13% DV), phosphorus (13% DV), tryptophan (12.5% DV). Smaller but measurable amounts of selenium (6% DV) round out the profile.
Intake considerations
A combination of nuts and seeds (including flaxseeds) totaling about 3 tablespoons (1.5 ounces, or 42 grams) per day is consistent with public health recommendations.
Flaxseeds, ground, raw
2.00 TBS
(14.00 grams)
Calories: 75
GI: very low
NutrientDRI/DV
omega-3 fats133%
vitamin B119%
copper19%
manganese18%
fiber15%
magnesium14%
phosphorus13%
selenium6%
- Health Benefits
- Description
- History
- How to Select and Store
- Tips for Preparing and Cooking
- How to Enjoy
- Individual Concerns
- Nutritional Profile
- References
Individual concerns
“Cyanide” is a term that we typically associate with the potentially deadly poison, hydrogen cyanide. However, there are very small amounts of cyanide constantly present and undergoing metabolism in human tissue. These small amounts of cyanide are found in relatively non-toxic forms like thiocyanates. Of course, these same thiocyanates are also found to occur naturally in foods (for example, in cruciferous vegetables). Linamarin and lotaustralin are two of the primary cyanogenic glycosides in flaxseeds, and like the thiocyanates in cruciferous vegetables, both of these compounds can contribute to cyanide metabolism in humans. However, as long as our metabolic processes are not overloaded and we are in reasonably good health, about two tablespoons of flaxseeds per day are likely to provide too little linamarin and lotaustralin to cause an adverse reaction. We’ve seen research on flaxseed meal, for example, which shows about 5-6 milligrams of cyanogenic glycosides (CGs) in one tablespoon. (And to give you a comparison, oral doses of sodium cyanide and potassium cyanide that cause acute and dangerous toxicity in humans fall into the range of 1000’s of milligrams.)
It’s not actually the CGs themselves that pose a risk, but their breakdown by an enzyme called beta-glucosidase that results in the release of hydrogen cyanide. When beta-glucosidase is unavailable or ineffective in breaking apart the CGs, we don’t get faced with the hydrogen cyanide risk. And even when beta-glucosidase does break apart the CGs, there’s an enzyme in our body called rhodanase that can convert hydrogen cyanide into the relatively non-toxic form of thiocyanate.
The issue of cooking and CGs in flaxseeds is somewhat ambiguous. We’ve see one study in which the baking of flax-flour containing muffins at 230F for 15-18 minutes showed no CGs in the final product. That result would point to a helpful impact of cooking on cyanide-related risk. We’ve also seen a study in which the overnight soaking of cassava, fermentation of cassava, as well as boiling, steaming, and dry heating of cassava all resulted in decreased CG content, with decreases falling into a very wide range of 32-99% range. While cassava is a food which can have the exact same amount of CGs as flaxseed, and in some cases, much higher amounts, it is also a food that is less compact and more porous than flaxseeds, and it would be expected to respond differently to cooking. In one study on commercial processing of flax, 20-30 minutes of heating at 150-221F did not appear to alter the CG content of the seeds or the processed flaxseed flakes or flaxseed cakes. From all of these studies, our overall conclusion is as follows: you may well benefit from the cooking of flaxseeds as a way of decreasing your cyanide-related risks, but you also may have no compelling reason to do so, since (1) the amount of CGs contained in 1-2 tablespoons is relatively small; (2) not all CGs will get broken down by enzymes and converted into hydrogen cyanide; and (3) if hydrogen cyanide does get created, most healthy persons will be able to detoxify it when it is present in such relatively small amounts.
Some people have gastrointestinal symptoms, such as flatulence and bloating, when they first begin to incorporate flaxseeds into their diet. It is suggested to start with a small amount, such as one teaspoon, and slowly build yourself up to your intake goal. When increasing fiber intake in the diet, it is also a good idea to include fluid (water) intake as well.
Several animal studies (involving rats and mice) have raised questions about the safety of high-dose flaxseeds during pregnancy—not for the pregnant females, but for their offspring. “High-dose” in these animal experiments has meant flax intake as 10% of the total diet, or about 4 tablespoons of flaxseed for every 2,000 calories. Although it is impossible to generalize from animal studies to humans, we recommend that women who are pregnant (or considering pregnancy) consult with their healthcare providers if they are consuming or planning to consume flaxseeds in these high amounts.
A high-performance blender like the Vitamix A3500 Ascent Blender fully breaks down seeds, stems, and frozen fruit for smooth, nutrient-dense smoothies.
Recipes with Flaxseeds
Full Nutrient Profile
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References
- Aberg UW, Saarinen N, Abrahamsson A et al. Tamoxifen and flaxseed alter angiogenesis regulators in normal human breast tissue in vivo. PLoS One. 2011; 6(9):e25720. Epub 2011 Sep 30. 2011. https://doi.org/10.1371/journal.pone.0061342
- Aliani M, Ryland D, and Pierce GN. Effect of flax addition on the flavor profile of muffins and snack bars. Food Research International, Volume 44, Issue 8, October 2011, Pages 2489-2496. 2011. https://doi.org/10.1016/j.foodres.2011.01.044
- Caroprese M, Marzano A, Marino R et al. Flaxseed supplementation improves fatty acid profile of cow milk. Journal of Dairy Science, Volume 93, Issue 6, June 2010, Pages 2580-2588. 2010. https://doi.org/10.3168/jds.2008-2003
- Chahal N, McCrindle B, Manlhiot C et al. aA 4-week randomized clinical trial of flaxseed supplementation in children with hypercholesterolemia. Canadian Journal of Cardiology, Volume 27, Issue 5, Supplement, September—October 2011, Page S339. 2011.
- Dodin S, Cunnane SC, Masse B et al. Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial. Nutrition, Volume 24, Issue 1, January 2008, Pages 23-30. 2008. https://doi.org/10.1016/j.nut.2007.09.003
- Faintuch J, Bortolotto LA, Marques PC et al. Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder. Nutr Hosp. 2011 Jan-Feb;26(1):208-13. 2011.
- Fofana B, Cloutier S, Kirby CW, et al. A well balanced omega-6/omega-3 ratio in developing flax bolls after heating and its implications for use as a fresh vegetable by humans. Food Research International, Volume 44, Issue 8, October 2011, Pages 2459-2464. https://doi.org/10.1016/j.foodres.2010.12.018
- Fukumitsu S, Aida K, Shimizu H et al. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutrition Research, Volume 30, Issue 7, July 2010, Pages 441-446. 2010. https://doi.org/10.1016/j.nutres.2010.06.004
- Hallund J, Tetens I, Bugel S et al. The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women. Nutrition, Metabolism and Cardiovascular Diseases, Volume 18, Issue 7, September 2008, Pages 497-502. 2008. https://doi.org/10.1016/j.numecd.2007.05.007
- Ibrugger S, Kristensen M, Mikkelsen MS et al. Flaxseed dietary fiber supplements for suppression of appetite and food intake. Appetite, Volume 58, Issue 2, April 2012, Pages 490-495. 2012. https://doi.org/10.1016/j.appet.2011.12.024
- Kristensen M, Jensen MG, Aarestrup J et al. Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type. Nutrition & Metabolism 9.1 (2012). 2012. https://doi.org/10.1186/1743-7075-9-8
- Landete JM. Plant and mammalian lignans: A review of source, intake, metabolism, intestinal bacteria and health. Food Research International, Volume 46, Issue 1, April 2012, Pages 410-424. 2012. https://doi.org/10.1016/j.foodres.2011.12.023
- Leyva DR, Zahradka P, Ramjiawan B et al. The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: Rationale and design of the FLAX-PAD randomized controlled trial. Contemporary Clinical Trials, Volume 32, Issue 5, September 2011, Pages 724-730. 2011. https://doi.org/10.1186/1471-2164-13-684
- Madhusudhan B. Potential Benefits of Flaxseed in Health and Disease - A Perspective. Agriculturae Conspectus Scientificus (ACS) Year: 2009 Vol: 74 Issue: 2 Pages/record No.: 67-72. 2009.
- Marpalle P, Sonawane SK, LeBlanc JG, et al. Nutritional characterization and oxidative stability of alpha-linolenic acid in bread containing roasted ground flaxseed. LWT - Food Science and Technology, Volume 61, Issue 2, May 2015, Pages 510-515. https://doi.org/10.3389/fphar.2022.865801
- Morais D de C, Moraes EA, Dantas MI de S et al. Heat Treatment and Thirty-Day Storage Period Do Not Affect the Stability of Omega-3 Fatty Acid in Brown Flaxseed (Linum Usitatissimum) Whole Flour. Food and Nutrition Sciences 2. 4 (Jun 2011): 281-286. 2011. https://doi.org/10.4236/fns.2011.24040
- Moriarty S. Omega-3s from Whole-Food Flaxseed. Cereal Foods World 51. 5 (Sep/Oct 2006): 257-259. 2006. https://doi.org/10.1094/cfw-51-0257
- Nassu RT, Dugan MER, He ML et al. The effects of feeding flaxseed to beef cows given forage based diets on fatty acids of longissimus thoracis muscle and backfat. Meat Science, Volume 89, Issue 4, December 2011, Pages 469-477. 2011. https://doi.org/10.1016/j.meatsci.2011.05.016
- Oomah BD, Der TJ, and Godfrey DV. Thermal characteristics of flaxseed (Linum usitatissimum L.) proteins. Food . Food Chemistry, Volume 98, Issue 4, 2006, Pages 733-741. 2006. https://doi.org/10.1016/j.foodchem.2005.07.017
- Patenaude A, Rodriguez-leyva D, Edel AL et al. Bioavailability of [alpha]-linolenic acid from flaxseed diets as a function of the age of the subject. European Journal of Clinical Nutrition63. 9 (Sep 2009): 1123-9. 2009. https://doi.org/10.1016/j.plipres.2016.07.002
- Patterson RE. Flaxseed and breast cancer: what should we tell our patients?. J Clin Oncol. 2011 Oct 1;29(28):3723-4. Epub 2011 Sep 6. 2011.
- Perez-jimenez J, Neveu V, Vos F et al. . Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition 64. S3 (Nov 2010): S112-20. 2010.
- Pruthi S, Thompson SL, Novotny PJ et al. Pilot evaluation of flaxseed for the management of hot flashes. J Soc Integr Oncol 2007; 5(3):106-12. 2007. https://doi.org/10.2310/7200.2007.007
- Rodriguez-Leyva D, Bassett CMC, McCullough R et al. The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid. Canadian Journal of Cardiology, Volume 26, Issue 9, November 2010, Pages 489-496. 2010. https://doi.org/10.1016/s0828-282x(10)70455-4
- Sainvitu P, Nott K, Richard G et al. Structure, properties and obtention routes of flaxseed lignan secoisolariciresinol: a review. Biotechnologie, Agronomie, Societe et Environnement 2012, 16(1): 115-124. 2012.
- Simbalista RL, Sauerbronn AV, Aldrighi JM et al. Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacteric Symptoms of Postmenopausal Women. The Journal of Nutrition140. 2 (Feb 2010): 293-7. 2010. https://doi.org/10.3945/jn.109.113886
- Smith VH and Jimmerson J. Flaxseed. Briefing No. 56. (Nov). Agricultural Marketing Policy Center, Montana State Univesity, Bozeman, MT. 2005. 2005. https://doi.org/10.1002/jsfa.898
- Sturgeon SR, Volpe SL, Puleo E et al. Dietary intervention of flaxseed: effect on serum levels of IGF-1, IGF-BP3, and C-peptide. Nutr Cancer. 2011;63(3):376-80. 2011. https://doi.org/10.1080/01635581.2011.535964
- Tarpila S, Aro A, Salminen I et al. The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone. European Journal of Clinical Nutrition56. 2 (Feb 2002): 157-65. 2002. https://doi.org/10.1038/sj.ejcn.1601298
- Taylor CG, Noto AD, Stringer DM et al. Dietary milled flaxseed and flaxseed oil improve N-3 fatty acid status and do not affect glycemic control in individuals with well-controlled type 2 diabetes. J Am Coll Nutr. 2010 Feb;29(1):72-80. 2010. https://doi.org/10.1080/07315724.2010.10719819
- Villeneuve S, Des Marchais LP, Gauvreau V, et al. Effect of flaxseed processing on engineering properties and fatty acids profiles of pasta. Food and Bioproducts Processing, Volume 91, Issue 3, July 2013, Pages 183-191. https://doi.org/10.1016/j.fbp.2012.09.002
- Wu H, Pan A, Yu Z et al. Lifestyle Counseling and Supplementation with Flaxseed or Walnuts Influence the Management of Metabolic Syndrome. The Journal of Nutrition 140. 11 (Nov 2010): 1937-42. 2010. https://doi.org/10.3945/jn.110.126300
- Young R and Ardith B. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutrition Journal Year: 2011 Vol: 10 Issue: 1 Pages/record No.: 44. 2011. https://doi.org/10.1186/1475-2891-10-44
- Chahal N, McCrindle B, Manlhiot C et al. aA 4-week randomized clinical trial of flaxseed supplementation in children with hypercholesterolemia. Canadian Journal of Cardiology, Volume 27, Issue 5, Supplement, September–October 2011, Page S339. 2011.
- Allman MA, Pena MM, Pang D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur J Clin Nutr 1995 Mar;49(3):169-78 1995. PMID:18190. https://doi.org/10.1016/0005-2744(77)90012-2
- Bazzano LA, He J, Ogden LG, Loria CM, Whelton PK. Dietary fiber intake and reduced risk of coronary heart disease in US men and women: the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Arch Intern Med. 2003 Sep 8;163(16):1897-904 2003. https://doi.org/10.1016/s0140-6736(12)61766-8
- Bronner F, Pansu D. Nutritional aspects of calcium absorption. J Nutr. 1999;129:9-12 1999. PMID:9915868. https://doi.org/10.1093/jn/129.1.9
- Brooks JD, Ward WE, Lewis JE, Hilditch J, Nickell L, Wong E, Thompson LU. Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. Am J Clin Nutr. 2004 Feb;79(2):318-25. 2004. PMID:14749240. https://doi.org/10.1093/ajcn/79.2.318
- Bruce A. Swedish views on selenium. Ann Clin Res 1986;18(1):8-12 1986.
- Buchanan HM, Preston SJ, et al. Is diet important in rheumatoid arthritis. Br J Rheumatol 1991 Apr;30(2):125-34 1991. https://doi.org/10.1093/rheumatology/30.2.125
- Buckley LM, et al. Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. Ann Intern Med 1996; 125:961-968 1996. https://doi.org/10.1172/jci3914
- Buckwalter JA, et al. ABO blood groups and disease. JAMA 1956; 162(13):1210-1214 1956. https://doi.org/10.1001/jama.1956.02970300010005
- Caballero B. Vitamin E improves the action of insulin. Nutr Rev 1993 Nov;51(11):339-40 1993. https://doi.org/10.1111/j.1753-4887.1993.tb03761.x
- Campbell MJ, Koeffler P. Toward therapeutic intervention of cancer by vitamin D compounds. Journal of the National Cancer Institute 1997; 89(3):182-185 1997. https://doi.org/10.1093/jnci/89.3.182
- Cappuccio FP, et al. Epidemiologic association between dietary calcium intake and blood pressure: a meta-analysis of published data. Am J Epidemiol 1995;142:935-945 1995. https://doi.org/10.1093/oxfordjournals.aje.a117741
- Carmel R. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997 Oct 66(4):750-759 1997. https://doi.org/10.1093/ajcn/66.4.750
- Carr AC, Zhu BZ, Frei B. Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). Circ Res 2000 Sep 1;87(5):349-54 2000. https://doi.org/10.1186/1471-2164-10-388
- Carter JP, et al. Hypothesis: Dietary management may improve survival from nutritionally linked cancers based on analysis of representative cases. Journal of the American College of Nutrition 1993; 12:209-226 1993. https://doi.org/10.1080/07315724.1993.10718303
- Chait A, Malinow MR, et al. Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease. Am J Clin Nutr 1999 Nov;70(5):881-7 1999. https://doi.org/10.1093/ajcn/70.5.881
- Chen YD, Coulston AM, et al. Why do low-fat high-carbohydrate diets accentuate postprandial lipemia in patients with NIDDM. Diabetes Care 1995 Jan;18(1):10-6 1995. https://doi.org/10.2337/diacare.18.1.10
- Cherbut C, Aube AC, et al. Effects of short-chain fatty acids on gastrointestinal motility. Scand J Gastroentero Suppl. 1997;222:58-61 1997. PMID:9145449. https://doi.org/10.1080/00365521.1997.11720720
- Chevront SN. The Zone diet and athletic performance. Sports Medicine 1999; 27(4): 213-228 1999. https://doi.org/10.2165/00007256-199927040-00002
- Chung TW, Yu JJ, Liu DZ. Reducing lipid peroxidation stress of erythrocyte membrane by alpha-tocopherol nicotinate plays an important role in improving blood rheological properties in type 2 diabetic patients with retinopathy. Diabet Med 1998 May;15(5):380-5 1998. https://doi.org/10.1155/2019/8562408
- Cleland LG, James MJ. Rheumatoid arthritis and the balance of dietary N-6 and N-3 essential fatty acids. Br J Rheumatol 1997 May;36(5):513-4 1997. https://doi.org/10.1093/rheumatology/36.5.513
- Clemente A. Enzymatic protein hydrolysates in human nutrition. Trends Food Sci Tech. 2000;11:254-262 2000. https://doi.org/10.1016/s0924-2244(01)00007-3
- Clementz GL, Schade SG. The spectrum of vitamin B12 deficiency. Am Fam Physician, 1990 Jan 41(1):150-162 1990.
- Colditz GA, Manson JE, et al. Diet and risk of clinical diabetes in women. Am J Clin Nutr 1992 May;55(5):1018-23 1992. https://doi.org/10.1093/ajcn/55.5.1018
- Connor SL, Connor WE. Are fish oils beneficial in the prevention and treatment of coronary artery disease. Am J Clin Nutr 1997 Oct;66(4 Suppl):1020S-31S 1997. https://doi.org/10.1093/ajcn/66.4.1020s
- Cook JD, Dassenko SA, Whittaker P. Calcium supplementation: effect on iron absorption. Am J Clin Nutr 1991;53:106-11 1991. https://doi.org/10.1093/ajcn/53.1.106
- Corsonello A, Ientile R, et al. Serum ionized magnesium levels in type 2 diabetic patients with microalbuminuria or clinical proteinuria. Am J Nephrol 2000 May-2000 Jun 30;20(3):187-92 2000. https://doi.org/10.1159/000013582
- Craig WJ. Iron status of vegetarians. Am J Clin Nutr 1994; 59(suppl): 1233S-7S 1994. https://doi.org/10.1093/ajcn/59.5.1233s
- Cunnane SC, Hamadeh MJ, Liede AC, et al. Nutritional attributes of traditional flaxseed in healthy young adults. Am J Clin Nutr 1995 Jan;61(1):62-8 1995. PMID:18200. https://doi.org/10.1016/0005-2760(77)90212-0
- Dagnelie PC, et al. High prevalence of rickets in infants on macrobiotic diets. American Journal of Clinical Nutrition 1990; 51(2):202-208 1990. https://doi.org/10.1093/ajcn/51.2.202
- Dagnelie PC, et al. Macrobiotic nutrition and child health: results of a population-based, mixed-longitudinal cohort study in The Netherlands. American Journal of Clinical Nutrition 1994; 59: 1187S-1196S 1994. https://doi.org/10.1093/ajcn/59.5.1187s
- Dangelie PC, et al. Stunting and nutrient deficiencies in children on alternative diets. Acta Paediatr Scand Suppl 1991; 374:111-8 1991. https://doi.org/10.1111/j.1740-8709.2011.00348.x
- Darlington G, Jump A, Ramsey N. Dietary treatment of rheumatoid arthritis. Practitioner 1990 May 8;234(1488):456-60 1990. https://doi.org/10.3109/07853899109147922
- Darlington LG, Ramsey NW. Review of dietary therapy for rheumatoid arthritis. Compr Ther 1994;20(9):490-4 1994. https://doi.org/10.1093/rheumatology/32.6.507
- Davis, RE. Clinical chemistry of vitamin B12. Adv Clin Chem 1984 24:163-216 1984. https://doi.org/10.1016/s0065-2423(08)60273-5
- Dawson-Hughes B, et al. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. Annals of Internal Medicine 1991; 115(7):505-512 1991. https://doi.org/10.7326/0003-4819-115-7-505
- de Valk B, Marx JJ. Iron, atherosclerosis, and ischemic heart disease. Arch Intern Med 1999 Jul 26;159(14):1542-8 1999. https://doi.org/10.1001/archinte.159.14.1542
- De Vriese AS, De Sutter JH, et al. Mild to moderate hyperhomocysteinaemia in cardiovascular disease. Acta Cardiol 1998;53(6):337-44 1998.
- Del Toma E, Lintas C, et al. Soluble and insoluble dietary fibre in diabetic diets. Eur J Clin Nutr 1988 Apr;42(4):313-9 1988.
- Delpre G, Stark P, and Niv Y. Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin supplementation. Lancet 1999 Aug 28 354(9180):740-741 1999. https://doi.org/10.1016/s0140-6736(99)02479-4
- Dexter JD, Roberts J, Byer JA. The five hour glucose tolerance test and effect of low sucrose diet in migraine. Headache 1978 May;18(2):91-4 1978. https://doi.org/10.1111/j.1526-4610.1978.hed1802091.x
- DiSilvestro RA. Zinc in relation to diabetes and oxidative disease. J Nutr 2000 May;130(5S Suppl):1509S-11S 2000. https://doi.org/10.1093/jn/130.5.1509s
- Dockray GJ, Varro A, et al. The gastrins: their production and biological activities. Annu Rev Physiol. 2001;63:119-139 2001. PMID:11181951. https://doi.org/10.1146/annurev.physiol.63.1.119
- Don BR, Schambelan M. Diabetes, dietary protein and glomerular hyperfiltration. West J Med 1987 Oct;147(4):449-55 1987.
- D'Adamo PJ. Gut ecosystems II: Lectins and other mitogens. The Townsend Letter for Doctors 1991 1991. https://doi.org/10.1111/j.1574-695x.2007.00343.x
- Eastwood, GL. Pharmacologic prevention of colonic neoplasms. Effects of calcium, vitamins, omega fatty acids, and nonsteroidal anti-inflammatory drugs. Cancer Causes Control 1997;8:786-802 1997. https://doi.org/10.1159/000171543
- Editors of Vegetarian Times. Vegetarian Times Complete Cookbook. Macmillan: New York, 1995 1995.
- Eibl NL, Kopp HP, et al. Hypomagnesemia in type II diabetes: effect of a 3-month replacement therapy. Diabetes Care 1995 Feb;18(2):188-92 1995. https://doi.org/10.2337/diacare.18.2.188
- el-Yazigi A, Hannan N, Raines DA. Urinary excretion of chromium, copper, and manganese in diabetes mellitus and associated disorders. Diabetes Res 1991 Nov;18(3):129-34 1991.
- Emmert DH, Kirchner JT. The role of vitamin E in the prevention of heart disease. Arch Fam Med 1999 Nov-1999 Dec 31;8(6):537-42 1999. https://doi.org/10.1001/archfami.8.6.537
- Ensminger AH, Ensminger, ME, Kondale JE, Robson JRK. Foods & Nutriton Encyclopedia. Pegus Press, Clovis, California 1983.
- Ensminger AH, Esminger M. K. J. e. al. Food for Health: A Nutrition Encyclopedia. Clovis, California: Pegus Press; 1986 1986. PMID:15210.
- Ercan N, Nuttall FQ, et al. Plasma glucose and insulin responses to bananas of varying ripeness in persons with noninsulin-dependent diabetes mellitus. J Am Coll Nutr 1993 Dec;12(6):703-9 1993. https://doi.org/10.1080/07315724.1993.10718362
- Facino RM, Carini M, et al. Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats. Life Sci 1999;64(8):627-42 1999. https://doi.org/10.1016/s0024-3205(98)00605-5
- Fahrer H, Hoeflin F, et al. Diet and fatty acids: can fish substitute for fish oil. Clin Exp Rheumatol 1991 Jul-1991 Aug 31;9(4):403-6 1991.
- Fenichel GM. Migraine in children. Neurol Clin 1985 Feb;3(1):77-94 1985. https://doi.org/10.1159/000228238
- Fennema OR (Ed.). Food chemistry. Second edition. Marcel Dekker, New York, 1985 1985.
- Festen HP. Intrinsic factor secretion and cobalamin absorption. Physiology and pathophysiology in the gastrointestinal tract. Scand J Gastroenterol Suppl. 1991;188:1-7 1991. PMID:1775933. https://doi.org/10.3109/00365529109111222
- Flax Council. Flax History. http://www.flaxcouncil.ca/hisindex.htm 2001.
- George SL, Polascik TJ, Albala M, Walther PJ, Moul J, Madden JF, Snyder DC, Hars V, Switzer BR, Vollmer RT, Demark-Wahnefried W. Flaxseed and prostate cancer risk. Journal of Clinical Oncology, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 1510. 2007. https://doi.org/10.1016/s0002-9343(01)00995-0
- Griel AE, Kris-Etherton PM, Hilpert KF, Zhao G, West SG, Corwin RL. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutr J. 2007 Jan 16;6:2. 2007. PMID:17227589. https://doi.org/10.1186/1475-2891-6-2
- Harper CR, Edwards MJ, DeFilipis AP, Jacobson TA. Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans. J Nutr. 2006 Jan;136(1):83-7. 2006. PMID:16365063. https://doi.org/10.1093/jn/136.1.83
- Kinniry P, Amrani Y, Vachani A, Solomides CC, Arguiri E, Workman A, Carter J, Christofidou-Solomidou M. Dietary flaxseed supplementation ameliorates inflammation and oxidative tissue damage in experimental models of acute lung injury in mice. J Nutr. 2006 Jun;136(6):1545-51. 2006. PMID:16702319. https://doi.org/10.1093/jn/136.6.1545
- Kurzer MS, Lampe JW, Martini MC, Adlercreutz H. Fecal lignan and isoflavonoid excretion in premenopausal women consuming flaxseed powder. Cancer Epidemiol Biomarkers Prev 1995 Jun;4(4):353-8 1995. PMID:18180. https://doi.org/10.1016/0005-2744(77)90239-x
- Lucas EA, Wild RD, Hammond LJ et al. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab 2002 Apr;87(4):1527-32 2002. https://doi.org/10.1210/jcem.87.4.8374
- Mandasescu S, Mocanu V, Dascalita AM, Haliga R, Nestian I, Stitt PA, Luca V. Flaxseed supplementation in hyperlipidemic patients. Rev Med Chir Soc Med Nat Iasi. 2005 Jul-Sep;109(3):502-6. 2005. PMID:16607740.
- Mantzioris E, James MJ, Gibson RA, Cleland LG. Nutritional attributes of dietary flaxseed oil. Am J Clin Nutr 1995 Oct;62(4):841-2 1995. PMID:18170. https://doi.org/10.1016/0005-2728(77)90093-7
- Miljanovic B, Trivedi KA, Dana MR, Gilbard JP, Buring JE, Schaumberg DA. Relation between dietary n-3 and n-6 fatty acids and clinically diagnosed dry eye syndrome in women. Am J Clin Nutr. 2005 Oct;82(4):887-93. 2005. PMID:16210721. https://doi.org/10.1093/ajcn/82.4.887
- Nesbitt PD, Thompson LU. Lignans in homemade and commercial products containing flaxseed. Nutr Cancer 1997;29(3):222-7 1997. PMID:18160. https://doi.org/10.1093/bja/49.7.681
- Paschos GK, Magkos F, Panagiotakos DB, Votteas V, Zampelas A. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr. 2007 Jan 31; [Epub ahead of print] 2007. PMID:17268413. https://doi.org/10.1038/sj.ejcn.1602631
- Pruthi S, Thompson SL, Novotny PJ, Barton DL, Kottschade LA, Tan AD, Sloan JA, Loprinzi CL. Pilot evaluation of flaxseed for the management of hot flashes. J Soc Integr Oncol. 2007 Summer;5(3):106-12. 2007. PMID:17761129. https://doi.org/10.2310/7200.2007.007
- Ueshima H, Stamler J, Elliott P, Chan Q, Brown IJ, Carnethon MR, Daviglus ML, He K, Moag-Stahlberg A, Rodriguez BL, Steffen LM, Van Horn L, Yarnell J, Zhou B. Food Omega-3 Fatty Acid Intake of Individuals (Total, Linolenic Acid, Long-Chain) and Their Blood Pressure. INTERMAP Study. Hypertension. 2007 Jun 4; [Epub ahead of print] 2007. PMID:17548718. https://doi.org/10.1161/HYPERTENSIONAHA.107.090720
- Wood, Rebecca. The Whole Foods Encyclopedia. New York, NY: Prentice-Hall Press; 1988 1988. PMID:15220. https://doi.org/10.1002/food.19770210206
- Parikh M, Maddaford TG, Austria JA, et al. A comprehensive review of flaxseed (Linum usitatissimum L.): health-affecting compounds, mechanism of toxicity, detoxification, anticancer and potential risk. Crit Rev Food Sci Nutr. 2023;63(2):1-17. https://doi.org/10.1080/10408398.2022.2092718